Clinical Research Directory

Inclusion Criteria: * Adult patients aged over 18 years * Patients with a positive blood culture for Gram-negative bacilli (Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii) with results reported on weekdays before 11:00 ante meridiem (AM) * Patients clinically suspected of infection * Treated with empirical antibiotic therapy including a β-lactam, among the standard list of antibiotics to be tested recommended by CASFM-EUCAST (European Committee on Antimicrobial Susceptibility Testing) for Enterobacterales/Pseudomonas and included in the Reveal Rapid AST System panel * Hospitalized in intensive care unit (ICU) for at least the next 24 hours * Written informed consent obtained from the patient or a relative for study participation (emergency consent) * Affiliated with the French social security system Exclusion Criteria: * Patients receiving withdrawal or limitation of care * Patients with an expected survival prognosis of less than 72 hours * Patients with bloodstream infections caused by Gram-negative bacilli other than Acinetobacter baumannii, Citrobacter freundii, Citrobacter koseri, Enterobacter cloacae, Escherichia coli, Klebsiella aerogenes, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa * Patients treated with antibiotic therapy not including a β-lactam * Polymicrobial bloodstream infections * Pregnant or breastfeeding women * Patients under legal protection (guardianship or conservatorship) * Participation in another interventional research study