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VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
Sponsor: Sahlgrenska University Hospital
Summary
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease. The projekt involves 3 larger studies, each with specific aims specified in detailed description below. The main study (study 1) compares imaging-based biomarkers-with liver biopsy to evaluate their correlation with histologically confirmed liver disease, including fibrosis, inflammation, and steatosis. The main question the overall project aims to answer is: • Can multiple novel imaging-based biomarkers, such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI), be used for detailed, non-invasive liver characterization in children, and if so, how should they be used?
Official title: Imaging-Based Biomarkers for Non-Invasive Pediatric Liver Diagnostics
Key Details
Gender
All
Age Range
Any - 25 Years
Study Type
OBSERVATIONAL
Enrollment
550
Start Date
2019-03-28
Completion Date
2032-12
Last Updated
2025-10-02
Healthy Volunteers
Yes
Conditions
Locations (1)
Department of Radiology, Queen Silvias Children´s Hospital,Gothenburg Sweden
Gothenburg, Västra Götaland County, Sweden