Clinical Research Directory

Inclusion Criteria: 1. Age: 50-80 years 2. Fasting glucose ≥ 100 mg/dL or HbA1c \> 5.6% 3. Own a smartphone (Apple iOS or Android OS) 4. Proficient in reading and speaking in English 5. An eating window ≥12 hour/day 6. Willing to travel to sports facilities for exercise training sessions 7. Participants on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, SLGT2 inhibitors, GLP1 receptor agonists other lipid-modifying drugs (including over-the counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed if on a stable dose for 6-months, but dose adjustments are not allowed during the study Exclusion Criteria: 1. Insufficient dietary logging on the mCC app during screening, defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart 2. Type 1 Diabetes or Insulin-dependent Type 2 Diabetes 3. HbA1C \> 9.0% 4. Use of sulfonylurea or insulin within the last 3 months (due to unknown safety with TRE) 5. Change in medications that could impact study outcomes within the past 6 months 6. Change in weight of \>4kg in the past 3 months 7. Systolic BP greater than 160 mmHg and/or diastolic BP greater than 110 mmHg at rest 8. Fasting LDL cholesterol greater than 250 mg/dL 9. Fasting triglycerides greater than 500g/dL 10. Variable work hours, such as working night shifts 11. Caregiver for a dependent requiring frequent nocturnal care/sleep interruptions 12. Active tobacco use, illicit drug use, or history of treatment for alcohol abuse in the past 5 years. 13. Travel involving a time zone change of more than 3 hours twice or more during the study period 14. Active treatment for inflammatory and/or rheumatologic disease 15. History of a major adverse cardiovascular event within the past year (acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke/transient ischemic attack) 16. Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation/atrial flutter are acceptable) 17. Previously diagnosed with sever aortic stenosis 18. Previously diagnosed with sever COPD (FEV1/FVC ratio \<.7 \& FEV1 (%predicted) \<49 19. Orthopedic impairments severely compromising exercise performance 20. BMI \<18.5 kg/m2 21. History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 6 months (i.e. hypothyroidism on a stable dose of thyroid replacement therapy is not an exclusion). 22. History of adrenal disease in the past 5 years 23. History of malignancy undergoing active treatment, except non-melanoma skin cancer, in the past 5 years 24. History of an eating disorder in the past 5 years 25. History of cirrhosis in the past 5 years 26. History of stage 4 or 5 chronic kidney disease or dialysis in the past 5 years 27. History of HIV/AIDs 28. Currently enrolled in weight-loss or weight-management program 29. Regularly engages in 100 minutes or more of structured exercise 30. VO2 max threshold is above average for that individuals age group \[78\] 31. Uncontrolled psychiatric disorder including prior hospitalization