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A Study to Evaluate Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
Sponsor: Vertex Pharmaceuticals Incorporated
Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
Official title: A Phase 2b/3 Adaptive, Randomized, Active-controlled Study Evaluating the Efficacy, Safety, and Tolerability of Povetacicept Versus Calcineurin Inhibitor in the Treatment of Primary Membranous Nephropathy
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
176
Start Date
2025-09-30
Completion Date
2028-12-29
Last Updated
2026-03-30
Healthy Volunteers
No
Conditions
Interventions
Povetacicept
Solution for Subcutaneous Injection.
Tacrolimus
Capsules for Oral Administration.
Locations (73)
Renal Associates
Montgomery, Alabama, United States
Southwest Kidney Institute, PLC (SKI) - Surprise
Surprise, Arizona, United States
Academic Medical Research Institute (AMRI)
Los Angeles, California, United States
Valiance Clinical Research - Internal Medicine
Tarzana, California, United States
Western Nephrology & Metabolic Bone Disease PC
Arvada, Colorado, United States
Bioresearch Partner
Miami, Florida, United States
CTR Oakwater, LLC
Orlando, Florida, United States
Clinical Site Partners, LLC - Orlando
Winter Park, Florida, United States
DaVita Clinical Research Columbus
Columbus, Georgia, United States
Georgia Nephrology
Lawrenceville, Georgia, United States
CARE Institute-Boise Kidney
Boise, Idaho, United States
NANI Research
Hinsdale, Illinois, United States
DaVita Clinical Research Edina
Edina, Minnesota, United States
Kidney Specialists of Southern Nevada
Las Vegas, Nevada, United States
Carolina Nephrology Greenville
Greenville, South Carolina, United States
Carolina Nephrology, PA
Spartanburg, South Carolina, United States
El Paso Kidney Specialists
El Paso, Texas, United States
Provecta Research Network
Houston, Texas, United States
DaVita Clinical Research Houston
Houston, Texas, United States
Davita Clinical Research San Antonio
San Antonio, Texas, United States
Utah Kidney Research
Salt Lake City, Utah, United States
Milwaukee Neprologists, SC
Wauwatosa, Wisconsin, United States
St George Private Hospital
Kogarah, Australia
University of Newcastle - John Hunter Hospital (JHH)
New Lambton Heights, Australia
Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP
São Paulo, Brazil
Beijing Tsinghua Changgung Hospital
Beijing, China
Peking University First Hospital
Beijing, China
The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
Xiangya Hospital of Central South University
Changsha, China
Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital
Chengdu, China
Dalian Municipal Central Hospital
Dalian, China
Dongguan People's Hospital
Dongguan, China
Fuyang People's Hospital
Fuyang, China
Guangdong Provincial People's Hospital
Guangzhou, China
The First Affiliated Hospital,Sun Yat-sen University
Guangzhou, China
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University
Huai'an, China
The Second Qilu Hospital of Shandong University
Jinan, China
Liu Zhou Works Hospital
Liuchow, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China
Nanyang Central Hospital
Nanyang, China
The First Affiliated Hospital of Ningbo University
Ningbo, China
Shanghai General Hospital
Shanghai, China
The First Hospital of Hebei Medical University
Shijiazhuang, China
The Second Hospital of Hebei Medical University
Shijiazhuang, China
Tai'an City Central Hosptial
Tai’an, China
Weifang People's Hospital
Weifang, China
Wuxi People's Hospital
Wuxi, China
The First Affiliated Hospital of Xi 'an Jiaotong University
Xi'an, China
The First Affiliated Hospital of Xiamen University
Xiamen, China
Yantai YuHuangDing Hospital
Yantai, China
Yichang Central People Hospital
Yichang, China
Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl
Allemagne, Germany
Klinikum St. Georg gGmbH - Nephrology
Leipzig, Germany
Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie
Leipzig, Germany
Universitaetsklinikum Wuerzburg - Innere Medizin, Nephrologie
Würzburg, Germany
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, Hungary
Azienda Ospedaliera Universitaria Federico II
Naples, Italy
Hallym University Sacred Heart Hospital
Anyang-si, South Korea
Korea University Anam Hospital - Nephrology
Seoul, South Korea
Kyung Hee University Hospital at Gangdong - Nephrology
Seoul, South Korea
Samsung Medical Center - Nephrology
Seoul, South Korea
Severance Hospital, Yonsei University Health System - Nephrology
Seoul, South Korea
Yongin Severance Hospital - Nephrology
Yongin-si, South Korea
Hospital Universitari Vall D Hebron
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Clinica Universidad de Navarra - Nefrología
Pamplona, Spain
Hospital Universitario Virgen de la Macarena - Nefrología
Seville, Spain
University Hospital of Derby and Burton NHS Foundation Trust - Royal Derby Hospital
Derby, United Kingdom
Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary
Doncaster, United Kingdom
NHS Lothian - Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
St George's University Hospitals NHS Foundation Trust - St George's Hospital- Renal Medicine
London, United Kingdom
The Royal Wolverhampton NHS Trust - New Cross Hospital
Wolverhampton, United Kingdom