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Walking for Hypothyroidism Trial (WHT)
Sponsor: University of Karachi
Summary
Women with hypothyroidism often report persistent fatigue, weight gain, autonomic dysregulation, and stress despite stable levothyroxine therapy. This single-center, parallel-group RCT will test whether a structured, supervised 12-week walking program improves basal metabolic rate (BMR) and psychophysiological outcomes compared with usual activity. One hundred twenty women aged 35-55 with stable primary hypothyroidism will be randomized 1:1 to intervention or control.
Official title: A Randomized Controlled Trial of a 12-Week Walking Program on Metabolic and Psychophysiological Outcomes in Women With Hypothyroidism
Key Details
Gender
FEMALE
Age Range
35 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-11-01
Completion Date
2026-06-30
Last Updated
2025-10-03
Healthy Volunteers
No
Conditions
Interventions
Supervised Walking Program
A structured walking program consisting of 30 minutes per session, 5 sessions per week, for 12 weeks at 55-65% of age-predicted maximum heart rate. Sessions will be supervised by an exercise physiologist, with adherence monitored by heart rate tracking and attendance logs. Participants will continue their standard levothyroxine treatment but will not begin any new structured exercise programs.
Locations (1)
University of Karachi
Karachi, Sindh, Pakistan