Clinical Research Directory

Inclusion Criteria:Clinically diagnosed vitiligo confirmed by a dermatologist. Stable vitiligo for at least 6 months (no new lesions or progression). Age between 18 and 60 years. Both male and female patients. Presence of localized or segmental vitiligo suitable for topical treatment. Willingness to avoid other vitiligo treatments (e.g., phototherapy, corticosteroids) during the study period. Able and willing to provide written informed consent and comply with study procedures - Exclusion Criteria:History of systemic or topical methotrexate use within the past 3 months. Unstable or rapidly progressive vitiligo during the last 6 months. Presence of other autoimmune or dermatologic disorders that could interfere with study evaluation (e.g., psoriasis, eczema, lupus). Known hypersensitivity or allergy to methotrexate or any gel/iontophoresis components. Hepatic, renal, or hematologic impairment (abnormal liver function or renal profile). Pregnant or breastfeeding women, or those planning pregnancy during the study period. Use of phototherapy, corticosteroids, or immunosuppressive therapy within the last 3 months. Metal implants or pacemakers, which may contraindicate iontophoresis \-