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Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
Sponsor: Mayo Clinic
Summary
The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2026-01-31
Completion Date
2028-06-01
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Tests of sympathetic inhibition
Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
Tests of above level sympathetic activation
Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
Testing of below level sympathetic activation
Cold pressor test of the foot and bladder pressor response will be tested.
Locations (1)
Mayo Clinic
Rochester, Minnesota, United States