Clinical Research Directory

Inclusion Criteria: Experimental Group： Aged 18-65 years, male or female. Meets the Rome IV diagnostic criteria for IBS The absence of organic gastrointestinal disease that could explain the symptoms. Provides informed consent and voluntarily signs the informed consent form. Control Group： Age and sex-matched to the IBS patient group. No history of chronic digestive diseases or current gastrointestinal symptoms. Has not used antibiotics, proton pump inhibitors, probiotics, or other medications known to affect gut microbiota within the past month. Provides informed consent and voluntarily signs the informed consent form. Exclusion Criteria: History of gastrointestinal surgery (excluding appendectomy). Presence of concomitant organic gastrointestinal diseases (e.g., inflammatory bowel disease, celiac disease, gastrointestinal tumors). Presence of severe concomitant cardiac, hepatic, renal, endocrine, hematologic, or neurological diseases. Long-term use of medications known to affect gastrointestinal motility (e.g., opioids). Pregnancy, lactation, or women planning a pregnancy. Conditions contraindicating the use of capsule endoscopy, such as dysphagia, or known gastrointestinal strictures, diverticula, or obstruction. Any other condition deemed by the investigator as unsuitable for participation in the study.