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Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
Sponsor: CND Life Sciences
Summary
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease and RBD? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems and RBD by loss of muscle atonia during REM sleep, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.
Official title: Detection of Phosphorylated Alpha-Synuclein in Colonic Tissue Biopsy During Routine Colonoscopy
Key Details
Gender
All
Age Range
40 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2025-11-04
Completion Date
2029-10
Last Updated
2026-02-11
Healthy Volunteers
No
Locations (1)
Digestive Disease Associates
Branford, Connecticut, United States