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Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years
Sponsor: Case Western Reserve University
Summary
This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK). Study eyes are assigned to receive either a cornea from a donor without diabetes or a cornea from a donor with diabetes in a masked fashion.
Official title: Diabetes Endothelial Keratoplasty Study (DEKS): Impact of Diabetes and Other Predictors on Corneal Transplant Endothelial Cell Loss and Success
Key Details
Gender
All
Age Range
30 Years - 93 Years
Study Type
INTERVENTIONAL
Enrollment
570
Start Date
2025-12-03
Completion Date
2030-04-30
Last Updated
2026-02-27
Healthy Volunteers
No
Interventions
Descemet membrane endothelial keratoplasty
Replacement of the recipient corneal endothelial and Descemet membrane with healthy tissue from a donor cornea.
Locations (14)
Georgia Eye Partners
Atlanta, Georgia, United States
Price Vision Group
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Kansas City Eye Clinic
Overland Park, Kansas, United States
Mid-Atlantic Cornea Consultants
Baltimore, Maryland, United States
The Wilmer Eye Institute/Johns Hopkins
Baltimore, Maryland, United States
University of Michigan/Kellogg Eye Center
Ann Arbor, Michigan, United States
Verdier Eye Center
Grand Rapids, Michigan, United States
Minnesota Eye Consultants
Bloomington, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Associated Eye Care
Stillwater, Minnesota, United States
Moyes Eye Center
Kansas City, Missouri, United States
Legacy Devers Eye Institute
Portland, Oregon, United States
Ophthalmic Partners
Bala-Cynwyd, Pennsylvania, United States