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Phase I Trial of pH Resections of GBM at VA
Sponsor: VA Office of Research and Development
Summary
Glioblastoma is an infiltrating tumor that is difficult to visualize in surgery and on standard images. A special pH (acid-base) related magnetic resonance imaging (MRI) has been developed to better see infiltrating tumor. In this safety study, the investigators will carry out increased levels of pH based resections of infiltrating tumor to assess the tolerability in VA populations.
Official title: Targeting Infiltrating Glioblastoma Via pH Sensitive Visualization of Tumor and pH Modulation Through Bicarbonate Transporter SLC4A4
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2026-07-01
Completion Date
2031-07-01
Last Updated
2026-02-13
Healthy Volunteers
No
Conditions
Interventions
pH MRI based resection of GBM
This will require a chemical exchange saturation transfer MRI followed by surgical resection based on this MRI.
Locations (1)
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States