Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Effect of Obicetrapib/Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome
Sponsor: NewAmsterdam Pharma
Summary
This study will be a placebo-controlled, double-blind, randomized, Phase 3 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both as a fixed-dose combination (FDC) with ezetimibe 10 mg and as monotherapy, on top of guideline-recommended lipid-lowering therapy in patients with metabolic syndrome and/or Type 2 Diabetes Mellitus.
Official title: A Placebo-Controlled, Double-Blind, Randomized, Phase 3 Study to Evaluate the Effect of Obicetrapib 10 mg and Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome (RUBENS Trial)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2025-12-11
Completion Date
2028-06
Last Updated
2026-09-09
Healthy Volunteers
No
Interventions
obicetrapib 10 mg + ezetimibe 10 mg FDC daily
FDC
Obicetrapib 10 mg
monotherapy
Placebo
placebo on top of guideline-recommended lipid modifying therapy
Locations (55)
Clinical Research Institute of Arizona
Sun City West, Arizona, United States
Scripps Health - Whittier Diabetes Institute
La Jolla, California, United States
UC SanDiego Health
La Jolla, California, United States
Western University of Health Sciences
Pomona, California, United States
UF Health Jackson
Jacksonville, Florida, United States
East Coast Institute of Research LLC
Jacksonville, Florida, United States
East Coast Institute of Research LLC
Lake City, Florida, United States
K2 Medical Research
Maitland, Florida, United States
Floridian Clinical Research
Miami Lakes, Florida, United States
Cardiovascular Center of Sarasote Foundation for Research and Education
Sarasota, Florida, United States
High Desert Heart
Meridian, Idaho, United States
Endeavour Health
Skokie, Illinois, United States
Louisville Metabolic and Atherosclerosis Research Center (L-MARC)
Louisville, Kentucky, United States
Eastern Maine Medical Center
Bangor, Maine, United States
MD Medical Research
Oxon Hill, Maryland, United States
Jefferson City Medical Group
Jefferson City, Missouri, United States
Montana Medical Research
Missoula, Montana, United States
Inspira Health - Internal Medicine Associates
Bridgeton, New Jersey, United States
Central New York Clinical Research
Manlius, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Velocity Clinical Research
Durham, North Carolina, United States
PharmQuest Life Sciences, LLC
Greensboro, North Carolina, United States
Centricity Research dba Lucas Research
Morehead City, North Carolina, United States
Summit Research Group
Munroe Falls, Ohio, United States
Diabetes & Glandular Disease Clinic, P.A.
Kingsport, Tennessee, United States
Baylor College of Medicine - Center for Cardiometabolic Disease Prevention (The Center for Cardiovascular Disease Prevention)
Houston, Texas, United States
Juno Research LLC - Medical Center
Houston, Texas, United States
PlanIt Research, PLLC
Houston, Texas, United States
Clinical Trials of Texas dba Flourish Research
San Antonio, Texas, United States
Burke Internal Medicine
Burke, Virginia, United States
Burke International Medicine DBA Manassas Clinical Research Center
Manassas, Virginia, United States
Universal Research Group
Tacoma, Washington, United States
Dien Servis s.r.o.
Humpolec, Vysocina, Czechia
DOCTOR MN s.r.o
Čáslav, Czechia
MUDr. Alena Váchová
České Budějovice, Czechia
MEDIKA Hradec Králové, s.r.o.
Hradec Králové, Czechia
Interni diabetologicka ambulance (Pratia)
Jílové u Prahy, Czechia
Diabetologie - Dr. Tomas Edelsberger
Krnov, Czechia
Pratia Pardubice a.s. (Pratia)
Pardubice, Czechia
Dieko s.r.o
Pilsen, Czechia
Nemocnice Na Františku
Prague, Czechia
Institut klinicke a experimentalni mediciny
Prague, Czechia
Fakultni Nemocnice (FN) v Motole (Motol University Hospital)
Prague, Czechia
Bethesda Diabetes Research Center
Hoogeveen, Drenthe, Netherlands
Rijnstate Ziekenhuis
Arnhem, Gelderland, Netherlands
Noordwest Ziekenhuisgroep - Alkmaar
Alkmaar, North Holland, Netherlands
Deventer Ziekenhuis
Deventer, Overijssel, Netherlands
Albert Schweitzer Ziekenhuis
Zwijndrecht, South Holland, Netherlands
Human-Care, s.r.o.
Košice, Košice Region, Slovakia
Pavol Jozef Šafárik University
Košice, Košice Region, Slovakia
Funkystuff s.r.o.
Nové Zámky, Nitra Region, Slovakia
MUDr. Žáková s.r.o.
Trenčín, Trenčín Region, Slovakia
DIA-GNOSIS, s.r.o.
Piešťany, Trnava Region, Slovakia
JAL s.r.o.
Trnava, Trnava Region, Slovakia
Nemocnicna a.s
Malacky, Slovakia