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RECRUITING
NCT07219602
PHASE3

A Study to Evaluate the Effect of Obicetrapib/Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome

Sponsor: NewAmsterdam Pharma

View on ClinicalTrials.gov

Summary

This study will be a placebo-controlled, double-blind, randomized, Phase 3 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both as a fixed-dose combination (FDC) with ezetimibe 10 mg and as monotherapy, on top of guideline-recommended lipid-lowering therapy in patients with metabolic syndrome and/or Type 2 Diabetes Mellitus.

Official title: A Placebo-Controlled, Double-Blind, Randomized, Phase 3 Study to Evaluate the Effect of Obicetrapib 10 mg and Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome (RUBENS Trial)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

300

Start Date

2025-12-11

Completion Date

2028-06

Last Updated

2026-03-10

Healthy Volunteers

No

Interventions

DRUG

obicetrapib 10 mg + ezetimibe 10 mg FDC daily

FDC

DRUG

Obicetrapib 10 mg

monotherapy

OTHER

Placebo

placebo on top of guideline-recommended lipid modifying therapy

Locations (20)

Clinical Research Institute of Arizona

Sun City West, Arizona, United States

Scripps Health - Whittier Diabetes Institute

La Jolla, California, United States

UF Health Jackson

Jacksonville, Florida, United States

East Coast Institute of Research LLC

Jacksonville, Florida, United States

East Coast Institute of Research LLC

Lake City, Florida, United States

Floridian Clinical Research

Miami Lakes, Florida, United States

Louisville Metabolic and Atherosclerosis Research Center (L-MARC)

Louisville, Kentucky, United States

MD Medical Research

Oxon Hill, Maryland, United States

Jefferson City Medical Group

Jefferson City, Missouri, United States

Montana Medical Research

Missoula, Montana, United States

Inspira Health - Internal Medicine Associates

Bridgeton, New Jersey, United States

Central New York Clinical Research

Manlius, New York, United States

Velocity Clinical Research

Durham, North Carolina, United States

Floridian Clinical Research

Greensboro, North Carolina, United States

Centricity Research dba Lucas Research

Morehead City, North Carolina, United States

Summit Research Group

Munroe Falls, Ohio, United States

Juno Research LLC - Medical Center

Houston, Texas, United States

Clinical Trials of Texas dba Flourish Research

San Antonio, Texas, United States

Burke Internal Medicine

Burke, Virginia, United States

Burke International Medicine DBA Manassas Clinical Research Center

Manassas, Virginia, United States