Clinical Research Directory

Inclusion Criteria: * Males and females less than 5 years of age * Cardiac operations utilizing CPB * Cardiac reoperations utilizing CPB Exclusion Criteria: * Patients greater than 5 years of age. * Any active SYSTEMIC noncardiac disease expected to raise patient baseline CRP levels to above normal levels (\>1mg/dL). Since CRP levels correlate with the severity of most skin disease, patients with active dermatitis issues on the day of surgery will be excluded from the study. Patients with autoimmune diseases including RA, SLE, IBD (Crohn's disease, ulcerative colitis), Kawasaki disease and patients experiencing active infections will be excluded from the study. * Any noncardiac disease not well controlled (ex. Asthma not properly controlled with medication, etc.) * Recent viral illness (ex. Positive COVID/flu test 30 days prior to surgery) * All patients receive solumedrol (10mg/kg dose) from anesthesia as part of the prebypass protocol. Any patient currently taking steroids will also be excluded from the study * Non-cardiopulmonary bypass cases (Off pump CoA, Vascular ring surgery, etc.) * ECMO patients * Emergent cases