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Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin
Sponsor: University of Maryland, Baltimore
Summary
The purpose of this study is to evaluate the ability of oral vancomycin in preventing Clostridioides difficile infection (CDI) in patients that are simultaneously receiving antibiotics. Participants in this study will be placed randomly into two groups. The oral vancomycin treatment group will receive oral vancomycin two times per day simultaneously with an antibiotic plus two additional days. The no oral vancomycin control group will receive the current standard of care, which is an antibiotic and no oral vancomycin. Participation in this study will last approximately 3 months.
Official title: Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin in Patients Treated With Systemic Antibiotic Therapy in a Community Hospital
Key Details
Gender
All
Age Range
65 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-03-01
Completion Date
2027-12-31
Last Updated
2026-01-07
Healthy Volunteers
Yes
Interventions
Vancomycin (POC)
A dosage of oral vancomycin 125 mg will be given twice daily for the duration of the concomitant antibiotic plus two additional days
Locations (1)
University of Maryland Baltimore Washington Medical Center
Glen Burnie, Maryland, United States