Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT07221838
PHASE4

A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

Sponsor: Alexion Pharmaceuticals, Inc.

View on ClinicalTrials.gov

Summary

This is a prospective, multicenter single arm study designed to evaluate the effectiveness and safety of a predefined oral corticosteroids (OCS) tapering schedule to reduce OCS use in adult participants with acetylcholine receptor positive (AChR+) generalized myasthenia gravis (gMG) being treated with intravenous ravulizumab.

Official title: OCTAGON: A Phase 4, Single Arm Study to Investigate Oral Corticosteroid Tapering in Adult Patients With Generalized Myasthenia Gravis Treated With Ravulizumab

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

75

Start Date

2026-03-04

Completion Date

2027-08-27

Last Updated

2026-04-09

Healthy Volunteers

No

Interventions

PROCEDURE

Oral Corticosteroid Tapering Schedule

During the tapering period, participant will follow an Oral Corticosteroid tapering schedule as applicable to the participant. The oral corticosteroid (prednisone/prednisolone) is provided as per standard medical care.

DRUG

Ravulizumab

Patients being treated with intravenous ravulizumab as part of their standard medical care.

DRUG

Prednisone/Prednisolone

Participants will continue with or be switched to prednisone/prednisolone as per standard medical care.

Locations (12)

Research Site

Chicago, Illinois, United States

Research Site

Schaumburg, Illinois, United States

Research Site

Neptune City, New Jersey, United States

Research Site

Raleigh, North Carolina, United States

Research Site

Knoxville, Tennessee, United States

Research Site

Bochum, Germany

Research Site

Milan, Italy

Research Site

Naples, Italy

Research Site

Rome, Italy

Research Site

Ibaraki, Japan

Research Site

Kitakyushu-shi, Japan

Research Site

Kumamoto, Japan