Clinical Research Directory
Browse clinical research sites, groups, and studies.
Tailored Exercise Training Study Among Adults With HFpEF
Sponsor: University of Texas Southwestern Medical Center
Summary
Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF. Exercise intolerance (EI) is the cardinal symptom of HFpEF, which manifests as dyspnea and fatigue. EI leads to functional deconditioning and reduced quality of life (QOL), both of which elevate risk of death and hospitalization in patients with HFpEF. Supervised exercised training is associated with improvements in exercise capacity and QOL in adults with HFpEF. However, supervised exercise has not been widely utilized for the treatment of HFpEF due to logistical and fiscal barriers. This study will investigate the effects of a remote exercise training intervention on exercise capacity and skeletal muscle composition in patients with HFpEF, or those at risk for it. In addition, it will compare four different lifestyle interventions for their effects on exercise capacity.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-02-18
Completion Date
2026-12-30
Last Updated
2025-10-31
Healthy Volunteers
No
Interventions
Moderate-intensity continuous training (MCT)
Tailored moderate-intensity exercise training video with weekly virtual meetings with a coach
Resistance training
Resistance training videos assigned to patient
Weight loss
Initiation/intensification of weight loss medications, such as semaglutide or tirzepatide
Locations (1)
University of Texas Southwestern Medical Center
Dallas, Texas, United States