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RECRUITING
NCT07223242
PHASE2/PHASE3

Tailored Exercise Training Study Among Adults With HFpEF

Sponsor: University of Texas Southwestern Medical Center

View on ClinicalTrials.gov

Summary

Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF. Exercise intolerance (EI) is the cardinal symptom of HFpEF, which manifests as dyspnea and fatigue. EI leads to functional deconditioning and reduced quality of life (QOL), both of which elevate risk of death and hospitalization in patients with HFpEF. Supervised exercised training is associated with improvements in exercise capacity and QOL in adults with HFpEF. However, supervised exercise has not been widely utilized for the treatment of HFpEF due to logistical and fiscal barriers. This study will investigate the effects of a remote exercise training intervention on exercise capacity and skeletal muscle composition in patients with HFpEF, or those at risk for it. In addition, it will compare four different lifestyle interventions for their effects on exercise capacity.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2025-02-18

Completion Date

2026-12-30

Last Updated

2025-10-31

Healthy Volunteers

No

Interventions

BEHAVIORAL

Moderate-intensity continuous training (MCT)

Tailored moderate-intensity exercise training video with weekly virtual meetings with a coach

BEHAVIORAL

Resistance training

Resistance training videos assigned to patient

DRUG

Weight loss

Initiation/intensification of weight loss medications, such as semaglutide or tirzepatide

Locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States