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ENROLLING BY INVITATION
NCT07223762
NA

Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

Sponsor: Vanderbilt University Medical Center

View on ClinicalTrials.gov

Summary

The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade versus use of a standard geometry video laryngoscope blade. Critically ill adults undergoing tracheal intubation in participating EDs and ICUs who meet eligibility criteria will be enrolled and randomly assigned in a 1:1 ratio to either intubation using a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade. The primary outcome is the incidence of successful intubation on the first attempt. The secondary outcome is incidence of hypoxemia during the interval between induction and 2 minutes after tracheal intubation.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2500

Start Date

2025-12-30

Completion Date

2027-05

Last Updated

2026-04-08

Healthy Volunteers

No

Interventions

OTHER

Hyperangulated video laryngoscope blade

Hyperangulated video laryngoscope blade

OTHER

Standard geometry video laryngoscope blade

Standard geometry video laryngoscope blade

Locations (16)

University of California, Los Angeles

Los Angeles, California, United States

Stanford University

Stanford, California, United States

University of Colorado, Denver Anschutz Medical Campus

Denver, Colorado, United States

Denver Health Medical Center

Denver, Colorado, United States

Rush University Medical Center

Chicago, Illinois, United States

Our Lady of the Lake Hospital, Inc.

Baton Rouge, Louisiana, United States

Ochsner Clinic Foundation

Jefferson, Louisiana, United States

University of Maryland Baltimore

Baltimore, Maryland, United States

Lahey Clinic, Inc

Burlington, Massachusetts, United States

Hennepin Healthcare component - Hennepin County Medical Center

Minneapolis, Minnesota, United States

Duke University Medical Center

Durham, North Carolina, United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

The Ohio State University

Columbus, Ohio, United States

Oregon Health & Science University

Portland, Oregon, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Baylor Scott & White Research Institute

Dallas, Texas, United States