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RECRUITING
NCT07224243
NA

Impact of Intraoperative Oxygenation Practices on Patient Outcomes

Sponsor: Frederic T Billings IV

View on ClinicalTrials.gov

Summary

This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

54000

Start Date

2025-12-01

Completion Date

2028-04

Last Updated

2026-04-07

Healthy Volunteers

No

Interventions

OTHER

Lower FiO2

FiO₂ 0.21-0.40 or lowest FiO₂ to maintain SpO₂ ≥ 94% during maintenance anesthesia

OTHER

Intermediate FiO2

FiO₂ 0.40-0.80 or lowest FiO₂ to maintain SpO₂ ≥ 94% during maintenance anesthesia

OTHER

Higher FiO2

FiO₂ \> 0.80 to maintain SpO₂ ≥ 94% during maintenance anesthesia

Locations (4)

University of Michigan Hospital

Ann Arbor, Michigan, United States

Nebraska Medical Center

Omaha, Nebraska, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

University of Utah Huntsman Cancer Institute

Salt Lake City, Utah, United States