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Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Sponsor: Stephanie B. Seminara, MD
Summary
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin. This study will utilize the technique of frequent blood sampling (q10 minutes) to provide detailed neuroendocrine characterization of endogenous LH secretion before and after kisspeptin administration. This frequency of blood sampling is required to define the features of LH pulses.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-03-10
Completion Date
2030-05
Last Updated
2026-03-31
Healthy Volunteers
No
Interventions
Kisspeptin 112-121
Single bolus of kisspeptin
Locations (1)
Massachusetts General Hospital
Boston, Massachusetts, United States