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RECRUITING
NCT07224490
PHASE1

Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

Sponsor: Stephanie B. Seminara, MD

View on ClinicalTrials.gov

Summary

The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin. This study will utilize the technique of frequent blood sampling (q10 minutes) to provide detailed neuroendocrine characterization of endogenous LH secretion before and after kisspeptin administration. This frequency of blood sampling is required to define the features of LH pulses.

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2026-03-10

Completion Date

2030-05

Last Updated

2026-03-31

Healthy Volunteers

No

Interventions

DRUG

Kisspeptin 112-121

Single bolus of kisspeptin

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States