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Exercise and Mortality in Middle-Aged and Older Adults
Sponsor: City of Hope Medical Center
Summary
This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).
Official title: Exercise and Mortality in Middle-Aged and Older Adults: A Target Trial Emulation
Key Details
Gender
All
Age Range
55 Years - 74 Years
Study Type
OBSERVATIONAL
Enrollment
19000
Start Date
2026-04-01
Completion Date
2026-08-06
Last Updated
2026-02-04
Healthy Volunteers
No
Conditions
Interventions
Control
0 or less than 1 day per week, with each session, on average \< 15 minutes.
Exercise
\>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.
Locations (1)
City of Hope Medical Center
Duarte, California, United States