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Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Sponsor: Shady Grove Fertility Reproductive Science Center
Summary
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).
Official title: A Randomized Blinded Controlled Trial Assessing Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
394
Start Date
2026-02-25
Completion Date
2027-07-01
Last Updated
2026-03-02
Healthy Volunteers
No
Conditions
Interventions
OCP pause
Subjects in the study arm will be asked to discontinue combined hormonal contraceptives (CHC) for 2 months prior to planned oocyte cryopreservation
Locations (3)
Yale Fertility Center
Orange, Connecticut, United States
Shady Grove Fertility Rockville
Rockville, Maryland, United States
Reproductive Medicine Associates of New York
New York, New York, United States