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Sex Differences in Neurobehavioral Response to THC
Sponsor: Medical University of South Carolina
Summary
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Official title: Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder
Key Details
Gender
All
Age Range
21 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-05-01
Completion Date
2027-12-31
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Dronabinol
Oral dronabinol capsules (40 mg)
Placebo
Matched placebo capsules
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States