Clinical Research Directory
Browse clinical research sites, groups, and studies.
Methadone in TKA for Post-op Pain and Opioid Reduction
Sponsor: Medical University of South Carolina
Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Official title: Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
162
Start Date
2026-01-08
Completion Date
2027-01-15
Last Updated
2026-02-04
Healthy Volunteers
No
Conditions
Interventions
Methadone Hydrochloride
Patients will intraoperatively be administered methadone 0.15mg/kg IV, based on ideal body weight.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States