Clinical Research Directory
Browse clinical research sites, groups, and studies.
Methadone Pharmacokinetics in Cardiac Surgery
Sponsor: Wake Forest University Health Sciences
Summary
Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and/or after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.
Official title: Evaluating Pharmacokinetics of Three Methadone Dosing Strategies During Cardiac Surgery With Cardiopulmonary Bypass
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
69
Start Date
2026-05
Completion Date
2026-12-30
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
Single dose of methadone
Single dose of methadone 0.3 mg/kg actual body weight (max 30 mg) administered at induction of anesthesia
Split dose of methadone
Split dose of methadone 0.2 mg/kg actual body weight at induction and 0.1 mg/kg actual body weight post cardiopulmonary bypass
Balanced split dose of methadone
Balanced split dose of methadone 0.15 mg/kg actual body weight at induction and 0.15 mg/kg actual body weight post cardiopulmonary bypass
Locations (1)
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States