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NOT YET RECRUITING
NCT07227779
PHASE2
B-PaLMZ for TB Meningitis
Sponsor: University of Minnesota
View on ClinicalTrials.gov
Summary
This two-stage study will compare consented research participants with tuberculous meningitis receiving BPaLMZ to controls receiving SOC of rifampicin (R), isoniazid (H), pyrazinamide (Z), and ethambutol (E), known as RHZE.
Official title: A PHASE 2 NOVEL ANTIMICROBIAL COMBINATION THERAPY TO TREAT TUBERCULOUS MENINGITIS
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-02-15
Completion Date
2030-08-31
Last Updated
2025-11-13
Healthy Volunteers
No
Conditions
Interventions
DRUG
BPaLMZ Regimen
bedaquiline, pretomanid, linezolid, moxifloxacin, and pyrazinamide
Locations (2)
University of Minnesota
Minneapolis, Minnesota, United States
Infectious Diseases Institute
Kampala, Uganda