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NOT YET RECRUITING
NCT07230028
PHASE4

Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.

Sponsor: Radboud University Medical Center

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are: Does addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis. Participants will: Take hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.

Official title: A Monocenter, Randomized, Double Blind Pilot Study Comparing Doxycycline in Combination With Hydroxychloroquine Treatment Versus Doxycycline Monotherapy in Patients With Long-Term Complaints Attributed to Lyme Borreliosis.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2026-03-01

Completion Date

2027-11-01

Last Updated

2025-11-17

Healthy Volunteers

No

Interventions

DRUG

Hydroxychloroquin

Added to the standard of care for Lyme Disease

DRUG

Placebo

Standard of care in combination with placebo

DRUG

Doxycycline

Standard of care