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Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
Sponsor: Radboud University Medical Center
Summary
The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are: Does addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis. Participants will: Take hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.
Official title: A Monocenter, Randomized, Double Blind Pilot Study Comparing Doxycycline in Combination With Hydroxychloroquine Treatment Versus Doxycycline Monotherapy in Patients With Long-Term Complaints Attributed to Lyme Borreliosis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-03-01
Completion Date
2027-11-01
Last Updated
2025-11-17
Healthy Volunteers
No
Conditions
Interventions
Hydroxychloroquin
Added to the standard of care for Lyme Disease
Placebo
Standard of care in combination with placebo
Doxycycline
Standard of care