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Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis
Sponsor: AbbVie
Summary
Idiopathic Pulmonary Fibrosis (IPF) is a rare, long-lasting lung disease that causes scarring of lung tissue, shortness of breath, and loss of lung function. IPF leads to significant loss of quality of life and shortened lifespan. This study is a platform study evaluating different types of treatments in patients with IPF. A platform study is a type of study that uses a single master protocol to evaluate different study treatments allowing for new study treatments or substudies to be added or closed over time. The main goals of the study are to evaluate the safety, tolerability (the degree to which the adverse symptoms can be handled by the patients during the study) and efficacy (how well study treatment works) of the study treatments, including ABBV-142 in Substudy 1 (SS1). ABBV-142 is an investigational drug being developed for the treatment of IPF. In SS1, participants will be randomly assigned to one of the 2 groups to receive either ABBV-142 or a matching placebo. This study is "double-blind", meaning that neither the participants nor the study doctors know who is given which study treatment. Approximately 165 adult participants with IPF will be enrolled in approximately 125 sites across the world. Participants will receive ABBV-142 or matching placebo for 52 weeks during the double-blind treatment period. Eligible participants may receive ABBV-142 for 52 weeks in open-label treatment period. All participants will be followed for 120 days. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Official title: A Phase 2a Multicenter Platform Study of Investigational Products for the Treatment of Adult Subjects With Idiopathic Pulmonary Fibrosis
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
165
Start Date
2026-01-23
Completion Date
2029-09
Last Updated
2026-08-24
Healthy Volunteers
No
Conditions
Interventions
ABBV-142
ABBV-142
Placebo for ABBV-142
Placebo for ABBV-142
Locations (49)
The University of Alabama at Birmingham /ID# 277613
Birmingham, Alabama, United States
Sec Clinical Research - East - Dothan - Graceland /ID# 278328
Dothan, Alabama, United States
Clinical Research Specialists - Kissimmee /ID# 279184
Kissimmee, Florida, United States
Christie Clinic on University /ID# 277871
Champaign, Illinois, United States
University of Michigan Health System - Ann Arbor /ID# 279994
Ann Arbor, Michigan, United States
Henry Ford Hospital /ID# 277843
Detroit, Michigan, United States
Hannibal Regional Hospital /ID# 277984
Hannibal, Missouri, United States
Jefferson Health Honickman Center /ID# 279127
Philadelphia, Pennsylvania, United States
Inova Fairfax Hospital /ID# 278469
Falls Church, Virginia, United States
Virginia Commonwealth University Medical Center /ID# 277992
Richmond, Virginia, United States
Lung Research Queensland /ID# 278838
Nundah, Queensland, Australia
Box Hill Hospital /ID# 278245
Melbourne, Victoria, Australia
University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski /ID# 277845
Pleven, Bulgaria
University Multiprofile Hospital For Active Treatment Sveti Georgi - Plovdiv /ID# 279367
Plovdiv, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 277846
Sofia, Bulgaria
Diagnostic Consultative Center Convex /ID# 277848
Sofia, Bulgaria
Diagnostic Consultative Center Convex /ID# 277849
Sofia, Bulgaria
Centre d'Investigation Clinique Mauricie /ID# 277949
Trois-Rivières, Quebec, Canada
Klinikum Konstanz /ID# 278139
Konstanz, Baden-Wurttemberg, Germany
Caritas-Krankenhaus St. Maria gGmbH /ID# 278138
Donaustauf, Bavaria, Germany
University General Hospital of Patras /ID# 277726
Pátrai, Achaia, Greece
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 277724
Athens, Attica, Greece
University General Hospital of Heraklion /ID# 277717
Heraklion, Crete, Greece
University Hospital of Ioannina /ID# 277719
Ioannina, Greece
General Hospital of Thessaloniki George Papanikolaou /ID# 277819
Thessaloniki, Greece
Vitamed Galaj i Cichomski Sp.j. /ID# 278145
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Unidade Local de Saude de Loures-Odivelas-Hospital Beatriz Angelo /ID# 278357
Loures, Lisbon District, Portugal
Unidade Local de Saude de Matosinhos EPE /ID# 277980
Senhora da Hora, Porto District, Portugal
Unidade Local de Saude do Algarve, EPE /ID# 278388
Faro, Portugal
University Clinical Center Serbia /ID# 278496
Belgrade, Beograd, Serbia
Institute For Pulmonary Diseases Of Vojvodina /ID# 278499
Kamenitz, Sremski Okrug, Serbia
Dr JM Engelbrecht Trial Site /ID# 278287
Somerset West, Western Cape, South Africa
Inje University Haeundae Paik Hospital /ID# 278000
Busan, Busan Gwang Yeogsi, South Korea
The Catholic University Of Korea, Bucheon St. Mary'S Hospital /ID# 278068
Bucheon-si, Gyeonggido, South Korea
Seoul National University Bundang Hospital /ID# 278059
Seongnam-si, Gyeonggido, South Korea
Yonsei University Health System Severance Hospital /ID# 278166
Seoul, Seoul Teugbyeolsi, South Korea
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 278029
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital /ID# 278043
Kaohsiung City, Taiwan
China Medical University Hospital /ID# 278039
Taichung, Taiwan
National Taiwan University Hospital /ID# 278041
Taipei, Taiwan
Taipei Veterans General Hospital /ID# 278038
Taipei, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 278042
Taoyuan City, Taiwan
Gulhane Egitim ve Arastirma Hastanesi /ID# 278944
Ankara, Antalya, Turkey (Türkiye)
Royal Papworth Hospital NHS Foundation Trust /ID# 278055
Cambridge, Cambridgeshire, United Kingdom
Edinburgh Royal Infirmary - NHS Lothian /ID# 278631
Edinburgh, Edinburgh, City of, United Kingdom
UCLH NHS FT - University College Hospital /ID# 279198
London, Greater London, United Kingdom
Royal Brompton Hospital /ID# 278007
London, Greater London, United Kingdom
University Hospital Southampton /ID# 278223
Southampton, Hampshire, United Kingdom
Norfolk and Norwich University Hospital /ID# 278224
Norwich, Norfolk, United Kingdom