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Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching an experimental drug called pozelimab (called "study drug"). The study is focused on people with a condition where certain parts of the eye's retina stop working over time, which can make it harder to see. This is called geographic atrophy (GA). The aim of the study is to see how safe and tolerable the study drug is when used as an injection in the eye. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Official title: A Phase 1 Dose-Escalation and Repeated-Dose Study of the Safety and Tolerability of Intravitreal Pozelimab in Participants With Geographic Atrophy
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2026-01-19
Completion Date
2028-07-03
Last Updated
2026-03-05
Healthy Volunteers
No
Conditions
Interventions
Pozelimab
Administered per the protocol
Locations (4)
Colorado Retina Associates
Lakewood, Colorado, United States
Ophthalmic Consultants of Boston
East Weymouth, Massachusetts, United States
Austin Retina Associates
Austin, Texas, United States
Retina Consultants Texas
The Woodlands, Texas, United States