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RECRUITING
NCT07230834
PHASE1

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

Sponsor: Regeneron Pharmaceuticals

View on ClinicalTrials.gov

Summary

This study is researching an experimental drug called pozelimab (called "study drug"). The study is focused on people with a condition where certain parts of the eye's retina stop working over time, which can make it harder to see. This is called geographic atrophy (GA). The aim of the study is to see how safe and tolerable the study drug is when used as an injection in the eye. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

Official title: A Phase 1 Dose-Escalation and Repeated-Dose Study of the Safety and Tolerability of Intravitreal Pozelimab in Participants With Geographic Atrophy

Key Details

Gender

All

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

54

Start Date

2026-01-19

Completion Date

2028-07-03

Last Updated

2026-03-05

Healthy Volunteers

No

Interventions

DRUG

Pozelimab

Administered per the protocol

Locations (4)

Colorado Retina Associates

Lakewood, Colorado, United States

Ophthalmic Consultants of Boston

East Weymouth, Massachusetts, United States

Austin Retina Associates

Austin, Texas, United States

Retina Consultants Texas

The Woodlands, Texas, United States