Clinical Research Directory

Inclusion Criteria: 1. Subjects must meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for Major Depressive Disorder (MDD), either single or recurrent episode. 2. Have a Hamilton Depression Rating Scale (HAM-D, 17-item) total score of 14 or higher at baseline. 3. Participants who are currently taking medications that may affect mood, sleep, or circadian rhythms (e.g., antidepressants, sedative antipsychotics, or sleep aids) may be included, provided that the dosage has remained stable for at least two weeks prior to enrollment. 4. Prior to inclusion, informed consent must be obtained. If cognitive impairment prevents subjects from signing, consent may be obtained from their primary caregiver (who may be a legal or professional representative). Exclusion Criteria: 1. Diagnosis of dementia of any severity, bipolar disorder, psychotic disorder, psychotic episode, or substance use disorder. 2. Active suicidal ideation or suicide attempt within the past three months. 3. Any other conditions deemed unsuitable for participation by the clinical physician, such as: * Currently experiencing acute delirium. * Suffering from respiratory infections, including COVID-19. 4. Participants with significant skin conditions on the head or conditions that could affect the efficacy of light therapy will be excluded. These include cases with: * Hemangiomas. * Scleroderma. * Psoriasis. * Rashes. * Open wounds. * Tattoos on the head. Additionally, individuals with head implants or those who have undergone photosensitizing drug treatments within two weeks prior to trial participation will also be excluded.