Clinical Research Directory

Inclusion criteria: * Ischemic Stroke * Age 18-70 years, no gender restriction * Confirmed anterior circulation occlusion by CTA or MR angiography (MRA) * Pre-stroke mRS score of 0-1 * Post-stroke ASPECTS score \>= 6 * Pre-enrollment NIHSS score\>= 6 * Within 24 hours to 14 days of stroke onset * Patients who have not received thrombolysis or endovascular treatment * No significant liver or kidney dysfunction: ALT and AST\<= 2.5 times the upper limit of normal, serum creatinine and blood urea nitrogen \<= 1.25 times the upper limit of normal * No significant cardiac dysfunction * The subject or legal representative can sign the informed consent form and comply with the requirements of the study for administration and follow-up. Exclusion criteria: * Intracranial hemorrhagic conditions observed on cranial CT: hemorrhagic stroke, epidural hematoma, subdural hematoma, intraventricular hemorrhage, subarachnoid hemorrhage, or hemorrhagic transformation, etc. * Known severe allergy to contrast agents (excluding mild rash-type allergies) * Known bleeding tendencies (including but not limited to): platelet count \< 100×10\^9/L; received heparin treatment within 48 hours with aPTT \>= 35s; currently taking warfarin with INR \> 1.7 * Patients with brain tumors, or a history of epilepsy and severe head trauma * Patients with other systemic malignancies * Patients with other serious systemic diseases such as immunodeficiency, coagulation disorders, etc. * Patients with Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases that prevent them from completing follow-up * Patients with severe local infection, systemic infection, immunodeficiency, or those currently taking immunosuppressants * Patients who are positive for hepatitis B surface antigen or currently suffering from other infectious diseases * Patients who have allergic reactions to the drug used in this study or similar drugs * Patients with known allergic constitution * Patients with nasal structural abnormalities or lesions * Patients with cerebrospinal fluid rhinorrhea * Patients who have participated in other clinical trials within the past 3 months * Unwilling or unable to comply with the procedures specified in the protocol * Pregnant or breastfeeding women, or women of childbearing potential who are unwilling or unable to use appropriate contraceptive measures * Patients clearly lacking the compliance to complete the clinical trial, such as those suffering from uncontrolled mental illness * Other situations deemed unsuitable for enrollment by the researchers