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RECRUITING
NCT07232589
PHASE1

A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.

Official title: A Study to Evaluate the Effect of Multiple Oral Doses of Diltiazem on the Single-Dose Pharmacokinetics of Nemtabrutinib in Healthy Participants.

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2025-12-08

Completion Date

2026-05-16

Last Updated

2026-04-08

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Nemtabrutinib

Oral administration

DRUG

Diltiazem

Oral administration

Locations (1)

Fortea CRU Madison ( Site 0001)

Madison, Wisconsin, United States