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Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
Sponsor: Hospital de Alta Complejidad en Red
Summary
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.
Official title: Incidence of Complications From the Alveolar Opening Maneuver in Mechanically Ventilated Children With Respiratory Distress Syndrome
Key Details
Gender
All
Age Range
1 Month - 14 Years
Study Type
OBSERVATIONAL
Enrollment
143
Start Date
2025-08-18
Completion Date
2026-08
Last Updated
2025-11-18
Healthy Volunteers
No
Conditions
Interventions
Alveolar Opening Maneuver and PEEP Titration (AOM+P)
Standardized ventilatory procedure performed in pediatric patients under invasive mechanical ventilation with acute respiratory distress syndrome (PARDS). The intervention consists of a controlled alveolar opening maneuver with stepwise PEEP increments up to a plateau pressure of 35 cmH₂O (or up to 40 cmH₂O in patients with reduced chest wall compliance), maintained for 2 minutes, followed by a decremental PEEP titration to determine the optimal PEEP level based on driving pressure and oxygenation response. The procedure is performed once clinically indicated, under continuous hemodynamic and oxygen monitoring, according to the institutional safety protocol.
Locations (1)
Hospital Cuenca Alta Néstor Kirchner
Cañuelas, Buenos Aires, Argentina