Inclusion Criteria:
* Male or female participants ≥18 years of age, and \<75 years of age.
* Participant is able to participate for the duration of the study
* Participant is willing to sign an informed consent form (ICF)
* Participant weighs \> 40kg
* Participants must be a non-smoker or not have smoked within 36 hours prior to the study
Exclusion Criteria:
* Participant self-reported prior injury or trauma to fingers or hands, which in the opinion of the investigator, may change blood flow or vascular supply and affect the ability to test sensors
* Physiologic abnormalities that prevent proper application of pulse oximetry sensor
* Severe contact allergies that cause a reaction to standard adhesive materials such as those found in medical sensors and electrodes
* Individuals of childbearing potential who are self-reported as pregnant, or who are self-reported as trying to get pregnant
* Morbid obesity (defined as BMI \> 39.5)
* Weight \> 136 kg
* Participants who self-report problems of unsteadiness or imbalance issues and/or who are unable to walk on a treadmill without holding onto the handrails
* Participant self-reported known heart or cardiovascular conditions such as:
* Uncontrolled hypertension (Systolic pressure ≥ 140mmHg or Diastolic pressure \> 90mmHg on 3 consecutive readings day of screening)
* Heart arrhythmias other than sinus arrhythmia (Self-reported and/or as identified on ECG day of screening).
* History of heart attack, blocked artery, history of myocardial ischemia, angina, myocardial infarction, congestive heart failure, cardiomyopathy, stroke, transient ischemic attack, or carotid artery disease
* Participants with self-reported clotting disorders, such as:
* History of bleeding disorders or personal history of prolonged bleeding from injury
* History of blood clots
* Hemophilia
* Current use of prescription blood thinner
* Participants with other self-reported, known health conditions, such as:
* Diabetes
* Thyroid disease
* Kidney disease / chronic renal impairment
* History of seizures (except childhood febrile seizures), epilepsy, or unexplained syncope
* Recent history of frequent migraine headaches, as determined medically relevant by the PI
* History of head injury, as determined medically relevant by the PI
* Cancer / chemotherapy
* Sickle cell disease
* History of hospital admission or a surgical procedure in the 60 days prior to study enrollment (self-reported)
* Participants with any contraindications to protocol specific repositioning techniques
* Unwillingness or inability to remove colored nail polish from test digit(s)
* Participants who have self-reported health conditions beyond what is captured in the prior exclusion criteria, which in the opinion of the Investigator and/or Clinical Staff would classify the participant as medically unsuitable
