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The SELEQT-HF (SELEnium and CoQ10 NuTrition for Heart Failure) Study Will Evaluate the Effect of Adding Selenium/and coQ10 on Top of Standard HF Therapy in Patients With HF and Will do so Using a Pragmatic, Registry Based Randomized Controlled Trial in the Netherlands.
Sponsor: Netherlands Heart Institute
Summary
The goal of this clinical trial is to learn whether taking selenium and coenzyme Q10 (CoQ10) can reduce HF related events and deaths related to cardiovascular disease. Researchers will compare selenium-CoQ10 supplements with a placebo to see if the supplements improve heart health and patient outcomes. Participants will: Receive either selenium-CoQ10 or placebo in addition to their usual heart failure treatment Attend standard clinical visits according to routine clinical care. The study will include 1,100 adults with chronic heart failure. Selenium and CoQ10 are natural nutrients with no known health risks. If effective, this supplement could provide a safe new way to improve outcomes for people with heart failure.
Official title: A Registry-Based Randomised Controlled Trial With Heart 4 Data - SELEnium and CoQ10 NuTrition for Heart Failure: H4D-SELEQT-HF
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1100
Start Date
2026-05-01
Completion Date
2030-12
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Selenium/CoQ10
Oral dosage of twice daily Selenium/CoQ10 (2 x 100 μg selenium tablets (SelenoPrecise 100 μg, Pharma Nord, Denmark) and 2 x 100 mg Q10 capsules (Bio-Quinon 100 mg B.I.D, Pharma Nord, Denmark)
Matching Placebo (B)
Matching Placebo
Locations (7)
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands
AUMC
Amsterdam, Netherlands
Amphia Ziekenhuis
Breda, Netherlands
Catharina ziekenhuis Eindhoven
Eindhoven, Netherlands
TREANT
Emmen, Netherlands
University Medical Center Groningen
Groningen, Netherlands
St Antonius ziekenhuis
Nieuwegein, Netherlands