Clinical Research Directory

Inclusion Criteria: * Patients who have unilateral and/or bilateral knee pain for more than 3 months and meet the diagnosis of osteoarthritis according to ACR criteria * Diagnosis of Stage II or III knee OA according to the Kellgren and Lawrence (K\&L) classification, determined by x-rays taken in the last 12 months * 40 mm above the pain level determined by VAS during rest for at least 15 days in the month before starting the study (for paracetamol and oral nonsteroidal anti-inflammatory drugs (NSAIDs), taking into account the half-life of the drug) * Having a Body Mass Index (BMI) ≤ 40 kg/m², * Having the mental ability to express pain scores * Signing the informed consent form indicating consent to participate in the study Exclusion Criteria: * Radiological K\&L stage I and IV * Acute inflammatory osteoarthritis attack (KOFUS ≥7) * Septic arthritis * Secondary OA \[Synovial chondromatosis or pigmented villonodular synovitis of the knee, Joint diseases (joint dysplasia, aseptic osteonecrosis, acromegaly, Paget's disease, hemophilia, hemochromatosis), Inflammatory diseases (rheumatoid arthritis, gout, infectious arthritis, acute calcium pyrophosphate arthritis)\] * Ipsilateral cruciate or collateral ligament injury in the last 3 months, * Corticosteroid injection into the target knee within the last 1 month before the first injection * Hyaluronat injection into the target knee within the last 6 months before the first injection * Arthroscopy or surgery on the target knee within the last 6 months before the first injection