Clinical Research Directory

Inclusion Criteria: 1. Adults aged 55 to 90 years. 2. Diagnosed with probable Alzheimer's disease according to NINCDS-ADRDA criteria and DSM-IV criteria for dementia, 3. or mild cognitive impairment/very mild Alzheimer's disease with CDR 0.5-1 and MMSE-II ≥18. 4. On stable cognitive therapy medications for at least 1 month. 5. Voluntary participation with signed informed consent. Exclusion Criteria: 1. Patients with structural brain lesions detected on brain MRI (e.g., cerebral edema, intracerebral hemorrhage, cerebral infarction, cerebrovascular malformation, brain tumor, etc.). 2. Patients with uncontrolled metabolic disorders such as thyroid dysfunction, hypoglycemia, or hepatic/renal impairment, or those on long-term medications that may cause cognitive impairment (e.g., anticholinergic drugs). 3. Patients with a history of epileptic seizures, depression, or psychiatric disorders; patients experiencing visual hallucinations or fluctuating cognitive decline. 4. Patients with psychiatric disorders outside of the inclusion criteria. 5. Patients with a history of severe diseases such as cancer or tuberculosis. 6. Patients with a history of or currently taking psychoactive drugs or medications affecting the central or peripheral nervous system. 7. Patients with contact dermatitis or other skin hypersensitivity conditions. 8. Patients with fever ≥ 40°C as measured by tympanic temperature. 9. Patients who have experienced bleeding within the past 3 months due to procedures or surgeries that may affect vital signs. 10. Patients unable to undergo MRI. 11. Pregnant patients. 12. Patients with clinical brain calcification observed on computed tomography (CT) scans. 13. Patients with known allergies to contrast agents such as Definity or Gadovist. 14. Any other condition deemed by the investigator to make participation in the clinical trial inappropriate.