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DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy
Sponsor: Tam Anh Research Institute
Summary
This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.
Official title: Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-12-01
Completion Date
2027-01-30
Last Updated
2025-12-30
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine + Desflurane
Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode.
Desflurane + Normal Saline
Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode.
Locations (1)
Tam Anh TP. Ho Chi Minh General Hospital
Ho Chi Minh City, Ho Chi Minh, Vietnam