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BMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement
Sponsor: Aya Adil Saeed
Summary
This randomized controlled clinical trial aims to evaluate the effect of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) on the stability and marginal bone level of dental implants following immediate placement. patients requiring extraction of unrestorable tooth in upper incisors or premolar region will be randomly assigned into two groups: the experimental group will receive immediate implant placement with rhBMP-2 application, while the control group will receive immediate implant placement without rhBMP-2. each group includes 16 immediate implants. Implant stability will be assessed using resonance frequency analysis (RFA) at baseline, and 16 weeks after implant placement. Marginal bone level changes will be evaluated radiographically using cone beam computed tomography (CBCT). The study aims to determine whether the use of rhBMP-2 enhances osseointegration and reduces marginal bone loss compared with conventional immediate implant placement.
Official title: Evaluating the Effect of Bone Morphogenetic Protein on Dental Implant Stability and Marginal Bone Level Following Immediate Implant Placement (Randomized Controlled Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2024-12-15
Completion Date
2026-01
Last Updated
2025-11-21
Healthy Volunteers
No
Interventions
rhBMP-2 placement
rhBMP-2 is mixed with BCP bone graft and placed in the jumping gap after immediate dental implant placement.
conventional immediate implant
Standard immediate dental implant placement procedure without adding of Bone Morphogenetic Protein in the bone graft placed in the jumping gap.
Locations (1)
University of Baghdad - College of Dentistry
Baghdad, Baghdad Governorate, Iraq