Clinical Research Directory

Inclusion Criteria: 1. Aged ≥30 and \<80 years, regardless of gender; 2. Confirmed diagnosis of hypertension meeting the criteria outlined in the 2024 Chinese Hypertension Guidelines: office blood pressure ≥140/90 mmHg and home blood pressure ≥135/85 mmHg; 3. Mild to moderate hypertension, with office blood pressure ranging from 140-179/90-109 mmHg; 4. No prior use of antihypertensive medications; 5. Voluntary participation in the study with written informed consent obtained. Exclusion Criteria: 1. Diagnosed or highly suspected secondary hypertension; 2. Classified as mixed type according to hemodynamic typing; 3. Allergy to the intended antihypertensive medications; 4. Dysphagia; 5. Pregnant or lactating women; 6. Potential pregnancy plans during the trial period; 7. Uncorrected electrolyte disturbances; 8. Severe organ dysfunction; 9. Comorbid conditions leading to inaccurate blood pressure measurement; 10. Comorbid conditions or states unsuitable for noninvasive hemodynamic measurement via bioelectrical impedance; 11. Comorbid conditions contraindicating or requiring caution with trial medications; 12. Comorbid conditions affecting the absorption, distribution, metabolism, or excretion of trial drugs; 13. Concurrent or planned use of medications contraindicated or requiring caution with trial drugs; 14. Concurrent or planned use of medications interfering with trial outcomes; 15. Clinician's assessment deems the patient unsuitable for the trial's antihypertensive regimen; 16. Current participation in other clinical studies that may interfere with the conduct of this trial.