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Antenatal Myo-inositol Supplementation in Pre-existing Diabetes
Sponsor: National University Hospital, Singapore
Summary
This feasibility pilot study aims to gather data that can guide the design of a larger, more comprehensive trial to establish the effects of myo-inositol supplementation on supporting healthy outcomes in pregnancies complicated by Type 2 Diabetes Mellitus (T2DM). It seeks to assess myo-inositol's potential to support fetal and neonatal health, and optimise maternity outcomes as a complementary approach and adjuvant to existing diabetes mellitus therapies, as well as investigate the underlying biological mechanisms.
Official title: Antenatal Myo-inositol Supplementation in Pre-existing Diabetes to Promote Normal Neonatal Outcomes
Key Details
Gender
FEMALE
Age Range
21 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
182
Start Date
2025-12
Completion Date
2029-08-31
Last Updated
2025-12-09
Healthy Volunteers
No
Interventions
Myo-inositol and folic acid supplement
Participants will take 4 capsules in the morning and 4 capsules in the evening, each capsule containing 500 mg of myo-inositol and 37.5 mcg of folic acid. Capsules are to be swallowed whole with a drink, starting from 12-16 weeks' gestation and continued until delivery.
Folic acid supplement
Participants will take 4 capsules in the morning and 4 capsules in the evening, each capsule containing 37.5 mcg of folic acid. Capsules are to be swallowed whole with a drink, starting from 12-16 weeks' gestation and continued until delivery.
Locations (1)
National University Hospital
Singapore, Singapore, Singapore