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Ongericimab Injection Reducing Recurrence of Ischemic Stroke
Sponsor: Beijing Tiantan Hospital
Summary
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C \< 1.4 mmol/L).
Official title: A Multicenter, Randomized, Open-label, Parallel-controlled, Event-driven, Blinded-endpoint Trial Evaluating the Efficacy and Safety of Ongericimab Injection in High-risk Stroke Patients With Intracranial or Extracranial Atherosclerotic Stenosis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4810
Start Date
2026-04-22
Completion Date
2029-04-01
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
High target group
Standardized lipid-lowering therapy according to the Chinese Stroke Association Guidelines for Clinical Management of Cerebrovascular Diseases to achieve an LDL-C target below 70 mg/dL (1.8 mmol/L)
Low target group
Ongericimab subcutaneous injection once every two weeks (150mg) or every four weeks(300mg) combined with standardized lipid-lowering therapy to achieve an LDL-C target below 55 mg/dL (1.4 mmol/L)
Locations (199)
Fuyang People's Hospital
Fuyang, Anhui, China
The First Affiliated Hospital of Wannan Medical College
Wuhu, Anhui, China
The First Hospital of Fangshan District, Beijing
Beijing, Beijing Municipality, China
Chongqing Sanbo Changan Hospital
Chongqing, Chongqing Municipality, China
The Fifth People's Hospital of Chongqing
Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College
Chongqing, Chongqing Municipality, China
Ningde People's Hospital
Ningde, Fujian, China
Minxian County Hospital of Traditional Chinese Medicine
Dingxi, Gansu, China
Shanghai General Hospital Jiuquan Hospital
Jiuquan, Gansu, China
Gansu Provincial Maternity and Child-care Hospital(Gansu Provincial Central Hospital)
Lanzhou, Gansu, China
The First People's Hospital of Yuzhong County
Lanzhou, Gansu, China
First People's Hospital of Tianshui
Tianshui, Gansu, China
Huizhou First Hospital
Huizhou, Guangdong, China
Huidong People'S Hospital
Huizhou, Guangdong, China
Shaoguan Qujiang District People's Hospital
Shaoguan, Guangdong, China
Wuchuan People's Hospital
Zhanjiang, Guangdong, China
Baise City People's Hospital
Baise City, Guangxi, China
Liuzhou Worker's Hospital
Liuchow, Guangxi, China
Puding County People's Hospital
Anshun, Guizhou, China
The People's Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture
Kaili, Guizhou, China
Tongren People's Hospital
Tongren, Guizhou, China
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Affiliated Hospital of Hebei University
Baoding, Hebei, China
Hebei Tang County People's Hospital
Baoding, Hebei, China
The No.2 Hospital Of Baoding
Baoding, Hebei, China
Cixian People's Hospital
Handan, Hebei, China
Weixian People's Hospital
Handan, Hebei, China
HanDan Central Hospital
Handan, Hebei, China
Qiuxian County People's Hospital
Handan, Hebei, China
Hejian People's Hospital
Hejian, Hebei, China
Hengshui People's Hospital
Hengshui, Hebei, China
The NO.4 People's Hospital of Hengshui
Hengshui, Hebei, China
The NO.4 People's Hospital of Hengshui
Hengshui, Hebei, China
Tianjin Cancer Hospital Qinhuangdao Branch
Qinhuangdao, Hebei, China
The Second Hospital of Qinhuangdao
Qinhuangdao, Hebei, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Xingtang County People's Hospital
Shijiazhuang, Hebei, China
Xinji Traditional Chinese Medicine Hospital
Shijiazhuang, Hebei, China
Guye District Hospital of Traditional Chinese Medicine, Tangshan
Tangshan, Hebei, China
Yutian County Hospital of Traditional Chinese Medicine
Tangshan, Hebei, China
Xingtai central hospital
Xingtai, Hebei, China
Xingtai People's Hospital
Xingtai, Hebei, China
Weixian People's Hospital
Xingtai, Hebei, China
Qinghe people's hospital
Xingtai, Hebei, China
Xuangang Hospital
Zhangjiakou, Hebei, China
Daqing No.4 hospital
Daqing, Heilongjiang, China
Daqing Oilfield General Hospital
Daqing, Heilongjiang, China
DA QING LongNan Hospital
Daqing, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
The 2nd Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Beian No.1 People's Hospital
Harbin, Heilongjiang, China
No.1 People'S Hospital of Heihe
Heihe, Heilongjiang, China
The First Affiliated Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
Mudanjiang Hospital of Beidahuang Group
Jixi, Heilongjiang, China
The Second Affiliated Hospital of Qiqihar Medical University
Qiqihar, Heilongjiang, China
Hongxinglong Hospital of Beidahuang Group
Shuangyashan, Heilongjiang, China
Hebi Coal Industry (Group) Co., Ltd. General Hospital
Hebi, Henan, China
Jiaozuo Coal Mining Group Co., Ltd. Central Hospital
Jiaozuo, Henan, China
The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People's Hospital)
Jiaozuo, Henan, China
Xiuwu County People's Hospital
Jiaozuo, Henan, China
Qinyang City Hospital of Traditional Chinese Medicine
Jiaozuo, Henan, China
Qinyang People's Hospital
Jiaozuo, Henan, China
Mengzhou Fuxing hospital
Jiaozuo, Henan, China
Mengzhou Hospital of Traditional Chinese Medicine
Jiaozuo, Henan, China
Jiyuan Hospital of Traditional Chinese Medicine
Jiyuan, Henan, China
Luoyang First People's Hospital
Luoyang, Henan, China
Luoyang Central Hospital
Luoyang, Henan, China
The Second Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
People'S Hospital of Tanghe
Nanyang, Henan, China
Pingdingshan The second people's hospital
Pingdingshan, Henan, China
The First People's Hospital of Pingdingshan
Pingdingshan, Henan, China
Chinese Medicine Hospital Of Puyang
Puyang, Henan, China
Puyang Oilfield General Hospital
Puyang, Henan, China
Puyang People's Hospital
Puyang, Henan, China
Puyang County People's Hospital
Puyang, Henan, China
Nanle People's Hospital
Puyang, Henan, China
Sanmenxia Central Hospital
Sanmenxia, Henan, China
Yellow River Sanmenxia Hospital
Sanmenxia, Henan, China
The First People Hospital of Lingbao
Sanmenxia, Henan, China
Shang Qiu Hospital of Tcm
Shangqiu, Henan, China
People's hospital of NingLing
Shangqiu, Henan, China
Sui county traditional Chinese medicine hospital
Shangqiu, Henan, China
The First Affiliated Hospital of Henan Medical University
Xinxiang, Henan, China
People's Hospital of Xixian
Xinyang, Henan, China
Changge People's Hospital
Xuchang, Henan, China
Xingyang People's Hospital
Zhengzhou, Henan, China
Xinmi Hospital of T.C.M
Zhengzhou, Henan, China
Zhoukou Yongshan Hospital
Zhoukou, Henan, China
Taikang Xian People's Hospital
Zhoukou, Henan, China
The First People's Hospital of Zhumadian
Zhumadian, Henan, China
Zhumadian Central Hospital
Zhumadian, Henan, China
The People's Hospital of Queshan County
Zhumadian, Henan, China
The People's Hospital Of Biyang County
Zhumadian, Henan, China
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
Xianning Central Hospital
Xianning, Hubei, China
Taoyuan People'S Hospital
Changde, Hunan, China
Liuyang Jili Hospital
Changsha, Hunan, China
Chenzhou 3rd People's Hospital
Chenzhou, Hunan, China
Chenzhou No.1 People's Hospital
Chenzhou, Hunan, China
Lianyuan People's Hospital
Loudi, Hunan, China
The Affiliated Hospital of Yongzhou Vocational and Technical College
Yongzhou, Hunan, China
Baotou City Central Hospital
Baotou, Inner Mongolia, China
Sinopharm North Hospital
Baotou, Inner Mongolia, China
Bayannur Hospital
Bayan Nur, Inner Mongolia, China
Wuyuan County People's Hospital
Bayan Nur, Inner Mongolia, China
Affiliated Hospital of Chifeng University
Chifeng, Inner Mongolia, China
Chifeng Hospital of Traditional Chinese and Mongolian Medicine
Chifeng, Inner Mongolia, China
Chifeng City Center Hospital Ningcheng County
Chifeng, Inner Mongolia, China
Ningcheng County Hospital of Traditional Chinese and Mongolian Medicine
Chifeng, Inner Mongolia, China
Tuoketuo County Hospital
Hohhot, Inner Mongolia, China
Tongliao People's Hospital
Tongliao, Inner Mongolia, China
Inner Mongolia Forestry General Hospital
Yakeshi, Inner Mongolia, China
Zhalantun Hospital of Traditional Chinese and Mongolian Medicine
Zhalantun, Inner Mongolia, China
Zhalantun People's Hospital
Zhalantun, Inner Mongolia, China
Lianshui County People's Hospital
Huai'an, Jiangsu, China
Siyang Kangda Hospital
Suqian, Jiangsu, China
The First People's Hospital of Jingdezhen
Jingdezhen, Jiangxi, China
Jiujiang No.1 People's Hospital
Jiujiang, Jiangxi, China
Yugan Xinjiang hospital
Shangrao, Jiangxi, China
China-Japan Union Hospital of Jilin University
Changchun, Jilin, China
Meihekou Central Hospital
Meihekou, Jilin, China
Siping City Central People's Hospital
Siping, Jilin, China
Tonghua Dongchang District People's Hospital
Tonghua, Jilin, China
General Hospital of Benxi Iron
Benxi, Liaoning, China
Benxi Central Hospital
Benxi, Liaoning, China
Central Hospital of Dalian University of Technology （Dalian Municipal Central Hospital）
Dalian, Liaoning, China
The first affiliated hospital of Dalian Medical University
Dalian, Liaoning, China
Dalian University Affiliated Xinhua Hospital
Dalian, Liaoning, China
Dalian lvshunkou district traditional Chinese medicine hospital
Dalian, Liaoning, China
Dalian Jinzhou District First People's Hospital
Dalian, Liaoning, China
Wafangdian Third Hospital Co., Ltd.
Dalian, Liaoning, China
Dandong Central Hospital
Dandong, Liaoning, China
Dandong First Hospital
Dandong, Liaoning, China
Liaoning Health Industry Group Fukuang General Hospital
Fushun, Liaoning, China
Huludao Central Hospital
Huludao, Liaoning, China
Northern Theater Command General Hospital
Shenyang, Liaoning, China
Central Hospital Affiliated to Shenyang Medical College
Shenyang, Liaoning, China
The First People's Hospital Of Shenyang
Shenyang, Liaoning, China
Northern Theater Command Air Force Hospital
Shenyang, Liaoning, China
The People's Hospital of Liaoning Province
Shenyang, Liaoning, China
The First Hospital of Xifeng County
Tieling, Liaoning, China
The Fifth People's Hospital of Ningxia
Shizuishan, Ningxia, China
The third hospital of shi zui shan
Shizuishan, Ningxia, China
Qinghai Provincial Traffic Hospital
Xining, Qinghai, China
Shenmu Hospital
Shenmu, Shaanxi, China
Xi 'an Fengcheng Hospital
Xi'an, Shaanxi, China
The Second Affiliated Hospital of Xi'an Medical University
Xi'an, Shaanxi, China
Zichang People's Hospital
Yan’an, Shaanxi, China
Yangxin County People's Hospital
Binzhou, Shandong, China
Binzhou Medical University Hospital
Binzhou, Shandong, China
People's Hospital of Qihe County
Dezhou, Shandong, China
Ningjin People's Hospital
Dezhou, Shandong, China
The Second People's Hospital of Dongying
Dongying, Shandong, China
Yuncheng County People's Hospital
Heze, Shandong, China
Qufu People's Hospital
Jining, Shandong, China
Liaocheng Brain Hospital
Liaocheng, Shandong, China
Liaocheng City Central Hospital
Liaocheng, Shandong, China
The Third People Hospital in Liaocheng
Liaocheng, Shandong, China
Liaocheng People's Hospital
Liaocheng, Shandong, China
The people's Hospital of Linqing
Liaocheng, Shandong, China
The People's Hospital of Gaotang
Liaocheng, Shandong, China
Qingdao Cardiovascular Hospital Co., Ltd.
Qingdao, Shandong, China
The Second Affiliated Hospital of Shandong First Medical University
Tai’an, Shandong, China
Weifang People's Hospital
Weifang, Shandong, China
People's Hospital of Gaomi
Weifang, Shandong, China
People's Hospital of Changle County
Weifang, Shandong, China
Weihai Central Hospital
Weihai, Shandong, China
Weihai Central Hospital
Weihai, Shandong, China
Weihai Wendeng District People's Hospital
Weihai, Shandong, China
Yantai Hospital of Traditional Chinese Medicine
Yantai, Shandong, China
YEDA hospital
Yantai, Shandong, China
Yantai Yuhuangding Hospital
Yantai, Shandong, China
Yantai Taocun Central Hospital
Yantai, Shandong, China
Qixia traditional Chinese medicine hospital
Yantai, Shandong, China
Yantai Penglai traditional Chinese medicine hospital
Yantai, Shandong, China
Liqun Hospital, Putuo District, Shanghai
Shanghai, Shanghai Municipality, China
Shanghai Fourth People's Hospital, Affiliated to Tongji University
Shanghai, Shanghai Municipality, China
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Changzhi People's Hospital
Changzhi, Shanxi, China
Linfen Central Hospital
Linfen, Shanxi, China
Grand Hospital of Shuozhou
Shuozhou, Shanxi, China
First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Shanxi Cardiovascular Hospital
Taiyuan, Shanxi, China
The First People's Hospital of Yangquan
Yangquan, Shanxi, China
Meishan Cardio Cerebrovascular Disease Hospital
Meishan, Sichuan, China
Suining Center Hospital
Suining, Sichuan, China
Jiang'an County Hospital of Traditional Chinese Medicine
Yibin, Sichuan, China
Xinjiang Production&Construaction Corps Hospital
Ürümqi, Xinjiang Uygur Autonomous Region, China
The People's Hospital of Nujiang Lisu Autonomous Prefecture
Nujiang, Yunnan, China
Ninger People's Hospital
Pu'er, Yunnan, China
HuZhou Central Hospital
Huzhou, Zhejiang, China
Haiyan People's Hospital
Jiaxing, Zhejiang, China
Lishui Central Hospital
Lishui, Zhejiang, China
Shaoxing people's hospital
Shaoxing, Zhejiang, China
Department of Yongjia People's Hospital
Wenzhou, Zhejiang, China
Affiliated Yueqing Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Beijing Tiantan Hospital, Capital Medical University
Beijing, China