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Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
Sponsor: National and Kapodistrian University of Athens
Summary
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms.
Official title: Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial.
Key Details
Gender
All
Age Range
38 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-11-24
Completion Date
2027-02
Last Updated
2025-12-02
Healthy Volunteers
No
Interventions
Dextrose 5% and Lidocaine
In the Dextrose + Lidocaine group (group D+L) a perineural infusion of a total volume of 8 ml of DW 5% and lidocaine 1% will be performed at the 4 genicular nerves (2ml per nerve), which will be prepared as follows: 4 ml of lidocaine 2%, with 1.2 ml of DW 35% and 2.8 ml of NaCl 0.9%. All perineural injections will be executed under ultrasound guidance 3 times (in 3 consecutive sessions): at their first assessment, 2 and 4 weeks later.
Lidocaine
In the Lidocaine group (group L) the respective infusion of a solution of 8 ml of lidocaine 1% at the 4 genicular nerves (2ml per nerve) will be prepared as follows: 4 ml of lidocaine 2% with 4 ml of NaCl 0.9%. The perineural injections in each group will be executed 3 times (in 3 consecutive sessions): at their first assessment, 2 and 4 weeks later.
Locations (1)
University General Hospital of Athens "Attikon" - National and Kapodistrian University of Athens Medical School
Athens, Attica, Greece