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Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I/II Sarcoidosis
Sponsor: China-Japan Friendship Hospital
Summary
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. This randomized controlled trial aims to compare directly the diagnostic yield between EBUS-TBMC and EBUS-TBNA+EBB+TBLB in sarcoidosis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
469
Start Date
2026-03-01
Completion Date
2026-12
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
EBUS-TBNA-based sampling methods
Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBNA.
EBUS-TBMC based sampling method
Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBMC.