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Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia
Sponsor: Asan Medical Center
Summary
This multicenter, prospective, single-arm study aims to evaluate the efficacy of inhaled nitric oxide (iNO) in neonates with congenital diaphragmatic hernia (CDH) and early pulmonary hypertension. Short-term treatment response will be assessed by the changes in oxygenation index and other parameters including echocardiographic parameters at predefined intervals.
Official title: Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia With Early Pulmonary Hypertension
Key Details
Gender
All
Age Range
1 Minute - 14 Days
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-11
Completion Date
2028-12
Last Updated
2025-11-25
Healthy Volunteers
No
Interventions
Inhaled Nitric Oxide
Inhalation of nitric oxide for 30 minutes in CDH approaching predefined criteria of moderate to severe pulmonary hypertension and define the short-term response
Locations (4)
Asan Medical Center
Seoul, Seoul, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Seoul National University Children's Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea