Clinical Research Directory

Inclusion Criteria: * Healthy adult males and females aged 18-60 years, inclusive * Body mass index (BMI) between 18 and 32 kg/m² and weight between 45 and 110 kg * Clinically normal medical history, physical exam, ECG, and laboratory results (or abnormalities deemed not clinically significant) * Willing and able to comply with study procedures and provide informed consent * Women of childbearing potential must use highly effective contraception and have negative pregnancy tests * Men must use contraception and refrain from sperm donation for 4 months post-dose * Completion of COVID-19 vaccination according to local guidelines, as well as influenza vaccination (within 12 months) Exclusion Criteria: * Prior treatment with investigational drugs within 30 days or 5 half-lives * Previous or current hypogammaglobulinemia * Current presence of allergic reactions considered clinically significant * Positive tests for HIV, hepatitis B/C, syphilis, or tuberculosis * Tobacco use (\>2 cigarettes/day), alcohol abuse, or drug abuse * Recent live vaccination (within 21 days) or any non-live vaccine (within 14 days)