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Motor Evoked Potential and Cortical Silent Period in Migraine
Sponsor: Istanbul Gelisim University
Summary
The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods. To this end, Motor Evoked Potential (MEP) and Cortical Silence Period (CSP) parameters obtained using Transcranial Magnetic Stimulation (TMS) will be measured and comparisons will be made between migraine patients and healthy controls. Since CSP duration is used specifically in the evaluation of GABA-B-mediated inhibitory mechanisms, it has the potential to directly measure the effect of migraine on cortical inhibition.
Official title: Investigation of Motor Evoked Potential and Cortical Silent Period in Migraine Patients
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-12-01
Completion Date
2026-02-01
Last Updated
2025-11-28
Healthy Volunteers
Yes
Conditions
Interventions
Transcranial Magnetic Stimulation (TMS)
Non-invasive brain stimulation applied to the primary motor cortex to elicit motor evoked potentials (MEP) and cortical silent periods (CSP). 70 mm figure-of-eight coil used with Magstim 200² Monophasic Stimulator.
Surface Electromyography (sEMG)
Bipolar Ag/AgCl electrodes placed over the first dorsal interosseous (FDI) muscle to record muscle responses to TMS.
Needle EMG / Single Motor Unit (SMU) Recording
Sterile Teflon-coated needle electrodes inserted into the FDI muscle to record activity of individual motor units during TMS and voluntary contractions.
Locations (1)
Istanbul Gelisim University, Faculty of Dentistry, Translational Dentistry Research Laboratory
Istanbul, Istanbul, Turkey (Türkiye)