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Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery
Sponsor: Ilsan Cha hospital
Summary
This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery requiring pneumoperitoneum and steep Trendelenburg positioning.
Official title: A Randomized, Parallel, Open-label With Blinded Assessment Study Comparing Hemodynamic Profiles Between Remimazolam- and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Robot-assisted Gynecologic Surgery
Key Details
Gender
FEMALE
Age Range
Any - 65 Years
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2026-05-02
Completion Date
2027-12-30
Last Updated
2026-03-27
Healthy Volunteers
No
Interventions
Remimazolam
Induction with remimazolam 6 mg·kg-¹·h-¹ with remifentanil Ce 4 ng·mL-¹ (Minto model); maintenance remimazolam 1-2 mg·kg-¹·h-¹, titrated (±0.2) to maintain PSI 25-50 and hemodynamic targets. Standard care otherwise per protocol.
Propofol
Induction with propofol Ce 4 ng·mL-¹ with remifentanil Ce 4 ng·mL-¹; maintenance propofol Ce 2.5-3.5 ng·mL-¹, titrated (±0.2) to maintain PSI 25-50 and hemodynamic targets. Standard care otherwise per protocol.
Locations (2)
CHA Ilsan Medical Center
Goyang-si, Gyeonggi-do, South Korea
CHA Ilsan Medical Center
Goyang-si, South Korea