Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

RECRUITING

NCT07252011

Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)

Sponsor: University of Pittsburgh

View on ClinicalTrials.gov

Summary

Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day

Official title: Restorative Neurophysiology: Feasibility of "Backup and Restore" Technologies for Brains and Bodies

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-01-01

Completion Date

2029-03-01

Last Updated

2026-03-03

Healthy Volunteers

Yes

Conditions

Adults With Variability in Their Mood

Interventions

DEVICE

Transcranial alternating current stimulation (tACS)

Transcranial alternating current stimulation (tACS) is a widely used non-invasive brain stimulation method. The concept underlying alternating current is to simulate the naturally occurring rhythmic pattern of electrophysiological activity of the brain, which can be detected by electroencephalography (EEG). It involves the application of electrodes onto the scalp, which deliver sinusoidal alternating electric currents.

BEHAVIORAL

Neuro/biofeedback

Participants will be shown their their brain EEG recordings and parameters from vocal recordings from their "backup" day, and asked to attempt to use behavioral strategies to match the recording

BEHAVIORAL

Recall

Participants will be given their subjective ratings and notes from a journaling interval to use as a target to restore their mood to how they were feeling on the Visit 1 backup day

DEVICE

Physiological stimulation

Facial electrical stimulation, and chest-worn vibroacoustic stimulation will be used to affect facial muscle activity and peripheral physiology to better approximate previously assessed states.

Inclusion Criteria: * Adults age 18-65 * have periods of good and bad moods each lasting at least 2 days Exclusion Criteria: * Refusal or inability to provide informed consent * People who report being in frank psychotic episodes or who say they are unable to stay off psychoactive substances during assessments will be excluded. Because we do not want to return participants to manic states, individuals with bipolar I disorder who report being or appear to be in a manic state at their baseline assessment will also be excluded. * Inability to complete questionnaires written in English. The justification is that many of the primary analyses involve assessment of change in self-reported symptoms using measures normed in English. Participants must thus be able to read those measures to give valid indications of the extent to which they have responded to the intervention. * Chronic pain that could be exacerbated by electrical stimulation * Having difficulties in corrected vision or hearing which would prevent efficient processing of the experimental stimuli * Having a North American Adult Reading Test (NAART) equivalent full scale IQ \< 85 * History of a convulsive disorder * Presence of any neurologic disorder or medication therapy known to decrease seizure threshold (e.g., brain injury, frequent/severe headaches). * Participants deemed "not a good fit" for the study for other reasons (such as, but not limited to, continually arriving late or rescheduling, not being a trustworthy historian or accurate reporter of symptoms, being belligerent with study staff, or presenting an active suicide risk) can also be excluded. * Heart condition * Current severe Diagnostic and Statistical Manual of Mental Disorders (DSM-V) alcohol or substance use disorder, with the exception of nicotine or caffeine. Clinician will access subjects' alcohol and substance use on a case-by-case to determine whether specific cases of mild or moderate alcohol or substance use would also interfere with the effects of the intervention. * Those who have metal implants in the vicinity of stimulated areas, or who have electrical implants (e.g., pacemakers, vagus nerve stimulator) will be excluded out of an abundance of caution regarding the safety of electrical stimulation. * Any metal implant or subcutaneous metal in the face or head

Locations (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States