Clinical Research Directory
Browse clinical research sites, groups, and studies.
Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia
Sponsor: Abbasi Shaheed Hospital
Summary
In this Study investigator is comparing the effectiveness and outcomes of two drugs used un the treatment of trigeminal neuralgia , Carbamazepine vs Oxcarbazepine
Official title: Comparison of Carbamazepine and Oxcarbazepine In the Treatment of Trigeminal Neuralgia
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
122
Start Date
2025-05-20
Completion Date
2025-12-01
Last Updated
2025-11-26
Healthy Volunteers
No
Conditions
Interventions
Carbamazepine
Carbamazepine is a conventional drug used to treat trigeminal neuralgia. It primarily works by blocking voltage-gated sodium channels in nerve cells, which prevents rapid and repetitive firing of action potentials and reduces abnormal electrical activity in the brain.
oxcarbazepine
Oxcarbazepine is comparatively new approved drug in the treatment of TGN. Oxcarbazepine is a prodrug that is rapidly converted to its active metabolite, (monohydroxy metabolite or MHD). This active form works by blocking voltage-sensitive sodium channels in the brain, which stabilizes over-excited nerve membranes and prevents the rapid spread of abnormal electrical activity
Locations (1)
Abbassi Shaheed hospital Facio-Maxillary Department
Karachi, Sindh, Pakistan