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BRCA Mutation Carriers' Platform a Multicenter Study
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
Subjects who carry mutations in breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2 genes) are at higher risk of developing cancers. Despite the cumulative amount of evidence published in the literature in the last two decades, the management of BRCA mutation carriers is still not completely defined. Since the prevalence of the mutation is estimated to be 1:400 - 1:500 individuals, the total number of BRCA mutation carriers should be around 140.000 - 150.000 in the Italian population. It is estimated that 87% of women with BRCA mutations will experience, in their lifetime, a tumor with a genetic origin. About 20% of the 5200 ovarian cancer cases diagnosed each year in Italy has a genetic origin and could potentially be the object of primary prevention. To date, and to the best of our knowledge, a national prospective data collection on women with BRCA mutations has not been yet established.
Official title: BRCA Mutation Carriers' Platform, a Multicenter Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10000
Start Date
2025-04-05
Completion Date
2045-12-31
Last Updated
2025-11-28
Healthy Volunteers
No
Conditions
Interventions
Registration of clinical datas in the platform
Registration of clinical datas in the platform of female individual carrying a BRCA1 or BRCA2 mutation
Locations (40)
Malzoni Research Hospital
Avellino, Italy
Centro di Riferimento Oncologico IRCCS
Aviano, Italy
Università degli Studi di Bari "Aldo Moro"
Bari, Italy
IRCCS Istituto Tumori "Giovanni Paolo II"
Bari, Italy
ASST Papa Giovanni XXIII
Bergamo, Italy
L'Azienda ospedaliera per l'emergenza "Cannizzaro"
Catania, Italy
Azienda Ospedaliero Santa Croce e Carle
Cuneo, Italy
Presidio Ospedaliero Umberto I - ASP di Enna
Enna, Italy
Azienda Ospedaliero Universitaria Careggi, Oncologia Medica Ginecologica
Florence, Italy
IRCCS Ospedale Policlinico San Martino
Genova, Italy
Ospedale S. Maria Goretti, Latina
Latina, Italy
Ospedale del Tigullio Polo di Lavagna - ASL 4 Chiavarese
Lavagna, Italy
Ospedale Vito Fazzi, Lecce
Lecce, Italy
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"
Meldola, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
Humanitas San Pio X - Milano
Milan, Italy
Presidio Ospedaliero di Mirano
Mirano, Italy
Fondazione IRCCS San Gerardo dei Tintori
Monza, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Italy
Ospedale Mater Olbia
Olbia, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, Italy
Azienda Ospedaliera Universitaria di Parma
Parma, Italy
Azienda Ospedaliero-Universitaria di Parma
Parma, Italy
Centro Nazionale di Adroterapia Oncologica
Pavia, Italy
Fondazione I.R.C.C.S. Policlinico San Matteo
Pavia, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Istituto Nazionale Tumori Regina Elena
Roma, Italy
Istituto Nazionale Tumori Regina Elena
Roma, Italy
Policlinico Umberto I Università "La Sapienza"
Roma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Ginecologia Oncologica
Rome, Italy
Azienda Ospedaliera Universitaria Senese
Siena, Italy
Ospedale G. Mazzini di Teramo
Teramo, Italy
Azienda sanitaria universitaria Friuli Centrale
Tolmezzo, Italy
Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino
Torino, Italy
Ospedale Mauriziano Umberto I
Torino, Italy
Azienda ULSS 2 MARCA TREVIGIANA
Treviso, Italy
IRCCS materno infantile Burlo Garofolo
Trieste, Italy
Azienda Ospedaliera Universitaria Integrata
Verona, Italy
AULSS 8 Berica
Vicenza, Italy